I have a small network running Windows XP, SP3/Windows 2003 & Active directory.
I had a user who had issues with Outlook crashing and an NK2 file that would not retain any entries, and had problems with Adobe Acrobat within Outlook. She needed to work, so instead of troubleshooting that issue right away, I replaced her PC and gave her a clean user account on the new PC. I only moved over the following user files:
1. MY DOCUMENTS
4. LOCAL SETTINGS/MICROSOFT/OUTLOOK/Archive.pst files (there were several)
5. APPLICATION SETTINGS/MICROSOFT/ OFFICE (.qat files).
I figured this would give her a clean start and she could work, and give me some time with the other issues on the other PC. Two days after giving her the new PC, Outlook began crashing on her. I disabled all the unecessary add ons and that seemed to be better, but we're still having an issue (note that Adobe is now not a problem in Outlook though). The most disturbing issue is that her particular user account is very very slow to load....about 1 minute to get past "applying personal settings". When I log in with my domain administrator account, there is no lag. I even logged in as the previous user of the machine (who still had a profile) and did not have an issue.
She IS an administrator on the machine. Safe mode has no lag. I would blow out this user profile again, but since this is was a clean user account I'm not convinced that will work. I am also not convinced that Outlook is not a culprit in this - we are on Exchange 2007.