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Segregate MAPI vs replication traffic if your Exchange 2010 DAG runs virtualized?

Maybe I'm just overtired but could someone explain to me if there is any benefit to segregating Exchange 2010 DAG traffic (MAP vs replication) if the entire environment is virtualized on VMware?  We will run a three-node DAG for a 200 user environment (overkill I know but better safe than sorry).  Please advise any pros or cons.  If the Exchange org was running of discreet servers I would defeinitely segregate the traffic with multiple NICs but not sure if it matters if our entire environment is virtualized running off clusterd ESX hosts.  Thanks.

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8/22/2022 - Mon
Marc Dekeyser

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Did provide additional reason to have separate NICs, either pnic or vnic.  
I was able to confirm segregation is not required for DAG to funtion properly via other research and that, in a virtualized environment, NIC segregation is not as critical in regards to network performance.
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