Site Collections are not opening which are created in particular Web Application?

Hi, I have created many Web Applications on SharePoint by Central Admin site and 3 or 4 Site Collections created in each and every Web Applications.

Now one Web Application’s site collections are not opening while last week these are all working, while other Web Application’s site collections are opening.

Please find attached message while opening sites in particular Web Application.
Kindly help.  

message.bmp
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prdeshpandeAsked:
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Justin SmithConnect With a Mentor Sr. System EngineerCommented:
Does the site still exist in IIS?  Does the app pool exist and running?
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Ivan PadabedConnect With a Mentor Director, Technology SolutionsCommented:
agree with ACH1LLES: please find your SP web application in IIS console by port number and check if its Application Pool is up and running.
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KoenVostersConnect With a Mentor Commented:
It is probably your site that is down in IIS. If the application pool alone would be down you would get a Service Error.
Also check your web applicatoin list in central admin to make sure the web application is still there.
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prdeshpandeAuthor Commented:
I have checked all the things and every thing is ok. BUT..........
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prdeshpandeAuthor Commented:
I want to share one more information.
Whenever I go in InetMgr and do right click on that SP Web Application Port and click on browse then site is opening.

Please find attached screenshot.

message.bmp
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KoenVostersConnect With a Mentor Commented:
Ok, but if you browse to it in your internet explorer things are not working right (on the server itself)
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prdeshpandeAuthor Commented:
Yes, not working on User machine and not on Server also
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KoenVostersConnect With a Mentor Commented:
The only thing I can think of is your proxy. Have you tried disabling the proxy?
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