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You can check if your IP is black listed <a href="http://www.dnsbl.info/" rel="ugc">http://www.dnsbl.info/</a><br />
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May be you exchange server is in open relay.
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You can check if your IP is black listed http://www.dnsbl.info/ [http://www.dnsbl.info/]

May be you exchange server is in open relay.

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And of course, some mail filters will scan your messages and look for signs that your sending spam - keywords and the like... 
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And of course, some mail filters will scan your messages and look for signs that your sending spam - keywords and the like...

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Does an ISP blacklist an email server if the volume of emails increases drastically? <br />
<br />
Once a week we will start sending thousands of emails to thousands of clients, apart from our normal email delivery. of course I expect some returns on invalid email addresses and such but I'm concerned that our ISP may see a drastic increase in our email flow once a week and might think were spammers and blacklist us.<br />
<br />
Should this be a concern?
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Does an ISP blacklist an email server if the volume of emails increases drastically? 

Once a week we will start sending thousands of emails to thousands of clients, apart from our normal email delivery. of course I expect some returns on invalid email addresses and such but I'm concerned that our ISP may see a drastic increase in our email flow once a week and might think were spammers and blacklist us.

Should this be a concern?

Determining how ISPs Blacklist a Mail Server

Exchange is the server side of a collaborative application product that is part of the Microsoft Server infrastructure. Exchange's major features include email, calendaring, contacts and tasks, support for mobile and web-based access to information, and support for data storage.

Exchange

Networking is the process of connecting computing devices, peripherals and terminals together through a system that uses wiring, cabling or radio waves that enable their users to communicate, share information and interact over distances. Often associated are issues regarding operating systems, hardware and equipment, cloud and virtual networking, protocols, architecture, storage and management.

Networking

Network Operations includes asset management, help-desk supervision, security and user policies, infrastructure administration and anything else that affects the operation of your network. Discussions will include those of best practices in platforms, configurations, performance, security and accounting.