I've just finished rolling out MS Office 2010 Plus throughout my organization and a frustrating issue has reared its head; when my users try to edit a document from any Shared Documents library on the Intranet site (MOSS 2007) , they're given an error by the Upload Center stating that a login is required. When they click on the 'Resolve' option, nothing happens.
This is where things get interesting. When I performed my testing, I did so on two virtual machines that exist on the same subnet as my Sharepoint server. No such errors with the Upload Center exist in that scenario. My users, however, are on a different subnet.
No other issues exist in regard to routing, so I'm convinced that this is local to either IIS or MOSS itself, but am so far stymied as to where to look. Network is 2003 R2 functional level with two Server 2008 R2 domain controllers.
Please let me know if any additional information is required to assist, and thanks for any tips.