I've mail enabled a list in share point (SBS 2008, Sharepoint 3, Exchange 2007). Everything works good when setting up the list. Sharepoint creates the contact and everything works fine for that. The problem is when I try to send an email to the contact created it gets stuck in the Exchange 2007 queue saything that there is a DNS 451 4.4.0 Primary Target IP Address responded with (421 4.2.1 Unable to Connect)..... I assume there must be a permissions problem somewhere or something. Sharepoint is running under the Network Service account and does have full control on the mail drop folder. Any help would be greatly appreciated. Thanks.