I have a PC running Windows Vista Home Premium. I updated my Microsoft Security Essentials program, and shortly afterward, my computer "Blue Screened". Anyway, I cannot log back into my PC. I can boot into safemode. I tried to uninstall M.S.E, but it won't uninstall in Safe mode. I ran MSConfig, and I checked off the M.S.E program so it wouldn't start. I also unchecked a few other unnecessary programs. I rebooted normally, and I still got the BSOD. I logged back into Safe Mode, and none of my original MSConfig changes took. The items were still checked. I definitely have admin rights. Also, I deleted the items from the HKLM\Software\Microsoft\Windows.........\Run\ key and rebooted. Same problem. When I entered back into Safe mode, the registy keys had been restored as if the changes never saved. Finally, I tried running System Restore, and I get an error on every Restore point, "The Requested Operation could not be performed. I also have Malwarebytes, and Norton 360 on my machine. I scanned for viruses, and the defs are up to date. No Viruses found. At this point, something is prohibiting me from saving configuration changes in Windows Vista safe mode. Any suggestions would be most appreciative!