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Outlook 421 Error Revisited

Posted on 2011-03-08
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Last Modified: 2013-11-30
I intermittently, but with increasing frequency get the following message

"The following recipient(s) could not be reached:
      '<name>' on 3/8/2011 12:26 PM
      421 Unexpected failure, please try later"

It appears that the same question was posed by:  darenceang on 3/2/08,  and that a knowledgeable response was posted by:  wart on 3/10/08.

My current problem is that I am on a site that is WAY OVER MY HEAD.  For example, Wart states that I should rename the <outcmd.data> and <frmcache.dat> file, but what should I rename it as?  Again, he suggested that the user "register" two important outlook files, but How?  It gets worse from there.

The problem appears common.  A simple google search shows 50 hits, but each one returns to a company selling Registry cleaning/fixing software.  I've bitten on 2 of them, without any results.

I'm using a home office computer with XP operating system and  Outlook 2002 or 2003 from Micro Office Suite with all applicable updates.   HELP!
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Question by:BewilderedNovice
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Acosta Technology Services earned 500 total points
ID: 35073191
The last time I saw this issue the fix was to remove add-ins in Outlook that were installed with iTunes.  I believe the name was "apple change notifier" or something to that effect.  I would remove any unnecessary add-ins within Outlook and test.
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by:BewilderedNovice
ID: 35073539
Thanks for a timely response. Your response gives me GREAT HOPE!   Wart had also suggested disabling add-ins, (it was one of the few suggestions that I understood), and I notice that itunes was one of them.   I've never used itunes, and don't intend to - nor do I understand how it got there.  Now, its trial and error to see if this intermittent error  continues.  I haven't marked my problem "solved" for that reason only.  

Thanks again, you can't imagine the frustration of repeatedly copying and resending messages, hoping it goes through and attempting to discern whether it was the attachments, the reply format, or ?? that created the problem.  
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by:Acosta Technology Services
ID: 35073614
You're welcome.  If you have a lot of add-ins it might be worth it to log in with the safe mode switch (from run:  outlook.exe /safe) which will load Outlook with no add-ins.  If you don't have any issues in safe mode then I would start removing add-ins (Apple first) until you find the culprit.  Let me know if you have any issues during the process.
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Author Comment

by:BewilderedNovice
ID: 35103776
Thanks so much.  I've actually been able to send about 20 messages without have to cut and paste resends.

One observation for anyone who will track this thread in the future.  Rather than just disable the itune add-in, I had to remove it entirely.  But, in retrospective, I might not have rebooted the Outlook program after disabling it, and that is why I had to remove it.

Thanks a second time
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Author Closing Comment

by:BewilderedNovice
ID: 35103814
Fast, courteous, and knowlegable
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Author Comment

by:BewilderedNovice
ID: 35133731
operationnos:, Help again?   The 421 error is back!  

The itunes add-in has been eliminated.  Now I get the error when I include an attachment of any size.   when I include an attachment, small or large.  The itunes add-in has been eliminated.

--bewildered novice
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Expert Comment

by:Acosta Technology Services
ID: 35133994
What if you start Outlook from safe mode?  Go to the run command, type "outlook.exe /safe"  ;  try and send with an attachment from there and see what happens.  Let me know.
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