Outlook OST can not be accessed when sending .doc file from Word or report from QuickBooks

When using the 'send as email' feature in Word, QuickBooks, or any third party software a error message pops up that reads "The file C:\users\username\appdata\local\microsoft\outlook\username.ost is in use and cannot be accessed. Close any application that is using this file, and then try again. You might need to restart your computer."

This computer was set up at the same time as 10 other windows 7 computers. Outlook uses hosted exchange settings and a backup PST was imported and then uploaded to the exchange site. Mail sends and receives normally. All other machines are working with similar setups.

I have repaired. I have created a new outlook profile with a new data file (in the same location.) I have done my best to verify the permissions are the same as other users.

2ndOf3Asked:
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2ndOf3Connect With a Mentor Author Commented:
It turns out that "run as administrator" was checked in the compatibility mode tab. After unchecking that box all programs and links to Outlook began working as designed.
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AdminmasterCommented:
To name a few;
Fax-software
Sync Software
Anti-virus/spam software
Anything else that does some sort of integration with Outlook or relies on
Outlook data.

Did you always have this issue? What did you do before you got this issue
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David-HowardCommented:
I understand that you re-created the profile. However, did you delete the ost file? If it is corrupted this could be the problem. Once Outlook is launched after OST deletion it will automatically create a new OST file. You will need to have Outlook closed in order to delete the OST.
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pcchiuCommented:
1.  How about disable all the add-on/plug in from outlook and see if it fixes the issue?
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RonProtronicsCommented:
Try this:
After you have pointed Outlook to your “Data File” via the “Data File” tab.
1. Choose “E-mail Accounts” / “Accounts Settings”.
2. Click the the “E-mail” tab.
3. Look for “Selected account delivers new messages to the following location:”
4. Look for the “Change Folder” button. Beside it you must see a nominated Inbox and path to the selected data file folder. (If there is not shown any email account/folder and path, then Outlook will continually generate various different and confusing error messages such as "Outlook data file cannot be accessed. Repair/reinstall office...” & “Cannot display the folder. Microsoft Outlook cannot access the specified folder location.”) If an “Inbox” folder and path is not shown do the following:
5. Click the button: “Change Folder”.
6. In the “New E-mail Delivery Location” dialogue box, browse for the “Inbox” in  your Outlook data file (or create new data file/folder).
7. Click “OK”.
The path to the selected data file should now be shown beside the “Change Folder” button.
Notes: For multiple accounts:
Choose a different folder WITHIN the Outlook datafile, click apply, and then change the delivery location back to the preferred “Inbox”.
If this does not work, Create a new, dummy PST file using the same Account Settings window and “Data Files” tab. Add a new temporary PST file. Then go back to step 4 above where you change the folder to where the selected account saves its email. Choose the PST that you have just added. Then click OK. Immediately go back into that dialog and change the folder location back to the original PST. Do the same for each account, then once done, remove the temporary PST.
If this does not work, you may have to delete and create/add a new e-mail account(s). In the “Account Settings”, select “New...” within in the “E-mail” tab. Select “Manually Configure Server Settings...” and in the “Internet Email” settings box you will see in the lower right corner, "Deliver New Messages to:" “New” or “Existing” Outlook data file. Select “Existing Outlook data file”. Browse to your file location and select your data file.
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Notes: For Exchange accounts:
If you getting an error on an Exchange account. Go to your Outlook ost and pst files folder. Delete the Exchange OST file and the OBI files. Then re-start Outlook.
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2ndOf3Author Commented:
Thanks for the tips, sorry for the delay in closing this question.
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