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Exchange 2010 451 4.4.0 Primary Target IP address responded 421 4.2.1 unable to connect.

have a new exchange 2010 installed into a forest with a 2007 server already running, the two exchange servers serve different domains, on the 2010 server all out going messages sit in queue with the error 451 4.4.0 Primary Target IP address responded 421 4.2.1 unable to connect., i have my send connector set to send to internet. I can ping mail.domain.com for a domain in queue and it replies, i can nslookup and it resolves fine, but i cannot telnet into it at all..any ideas?

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zulumike

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MegaNuk3

Has this only just happened recently? Have you tried the message flow troubleshooting assistant in the Toolbox?Does the Exchange 2010 server have it's own Send Connector? Are any Send Connectors set to deliver to a Smart Host or do they send direct to the Internet via DNS?

jasonmichel

ASKER

Firewall is fine.. running server2008 yes own send connector sending to internet..this is fresh install

jasonmichel

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Firewall is fine.. running server2008 yes own send connector sending to internet..this is fresh install

MegaNuk3

Uninstall AV / EPO / firewall off the Exchange 2010 server and then see if messages start flowing or not.

Does your server have more than 1 NIC installed?

jasonmichel

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firewall is off, and there is no AV installed yet. Yes server only has 1 nic

jasonmichel

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heres something odd, i can't telnet to any outside mailserver from inside the network on 25, i wonder if a firewall gpo could be the problem?

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MegaNuk3

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