Red Hat Ent 5 Disaster Planning

Background:  I have a Red Hat Enterprise 5 server in a production environment.  It is a quad core 4gb machine w/ the OS on a hardware Raid 1 setup.  It runs one software application managed via ssh from the software company located in Austria; they completely maintain this application.  Each night we backup the directory specified via the software company.  I am not confident that this backup is enough, this is an absolute mission critical application for the company.  I check daily the hard-drives (visually ensure that the lights are not indicating hard drive failure) and that the backups run and transfer duplicate backups offsite each night.   I am not fluent in Linux, and know only the basics, probably quite a bit less.  What is the best method to make a complete backup or clone or virtual clone of this system?  I am looking for a solution that could be restored "quickly" should a disaster occur.  My concern with Ghost or Acronis is that as the server is 2 years old, finding the identical hardware may be a concern.  My concern with a virtual system is that there is a Serial Modem attached to this system for faxed quotations on the sales side and have not had great luck with serial ports on VM's.