OOF issues with exchange 2010 sp1

We have exchange 2003 and migrated 200 users so far over to exchange 2010.  We have Windows 2008 R2 and exchange 2010 sp1.  Here is the strange issue we are having with OOF (out of office).  We have been getting reports from users that have been moved from 2003 to 2010, they have enabled the OOF and the replies aren’t responding.  We are also getting calls about others who have enabled the OOF and have selected to disable from the outlook client or owa and it still sending out the replies.   So for some they enable OOF but get no reply and others they have it enable but won’t turn off even though they have it selected to be off.  The weird thing about this is I have two mailbox servers with the DB’s on each.  If I move the user mailbox from one mailbox db to the other it starts to work and vice versa.  The services are running for the mailbox assistant.  Now we have netapp sans which we have the snapdrive and snapmanager for exchange running for backup of the DB’s every hour.  We also have trendmicro scanmail installed.  We have 3 cas/hub servers in an array.
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yes, your action plan is correct.
>>If I move the user mailbox from one mailbox db to the other it starts to work and vice versa

IMO, having third party solutions might cause this issue

Can you have a DB without the impact the 3rd pary ..then have the mailboxes over there...OOF should work here without any issues...

do you have BES also in picture?
If yes, check for the latest update from them.
hbpubAuthor Commented:
Had MS involved and at one point during our process of gathering information the two mailbox servers restarted and now it the OOF  works.

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hbpubAuthor Commented:
The problem went away once the servers rebooted.
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