Are there any patches known to cause issues with Exchange 2010?

I recently inherited an Exchange 2010 box that has not been patched in quite some time. Have there been any issues with any windows 2008 or Exchange 2010 patches that are known to have negative impacts/issues  on Exchange 2010?

jdjames21Asked:
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Glen KnightCommented:
Only Rollup  3 for Exchange 2010 SP1 which was removed from Microsoft Download site pretty promptly.

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