Exchange 2007 servers getting 399 errors

The client has 5 mailbox stores that the mail keeps getting corrupted. They keep getting the error 399 on them. They just created 2 new exchange 2007 servers and now they are getting the correuption also. The mail seems to be hanging in the submissions queues for a long time also before getting delievered.
Any ideas on what we can try to get rid of the corruption or what to look at?
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Please refer this URL

And let me know if it help to resolve the issue.

Thank you.
vmichAuthor Commented:
iSSUE WAS WITH THE SAN that the server was connected to...

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vmichAuthor Commented:
SAN issue
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