This is a new and odd issue and one that appears to be a culprit of some Malware, virus or something.
One of the computers in a chain of Retail stores that I Manage has appeared to lose all the store manager who uses it, documents and customizations (i.e. quick links etc.) However other data and programs still exist. And the computer works runs all of our retail programs like it should. It doesn't appear to be a complete data wipe or hard drive failure etc. You still can log in under his user account and outlook is still there and his .ost and .pst files associated are still there. However, all the docs in his "my documents" file are gone. His desktop had a ton of files and shortcutted programs and those are all gone. His quick links toolbar is gone. Nothing is in the recycle bin. More weirdness: when I go to "all programs" and right click and program and go to "send to" my option to send it to the desktop as a shortcut is missing. I can't think of what it could be especially since some things are there and some aren't.
Any ideas? Malware or a Virus, Unfortunately we don't have any backups either to restore. This computer is not backed up.