Best HelpDesk Solution for Medium Sized Company

We are a mid-sized company looking to replace our existing help desk system with something with a more robust feature-set.  We have a small but important feature set we're looking for:
-  Robust out of box reporting capabilities
-  End user self-service options (knowledge base look-up, password reset (nice to have), etc.)
-  End users to submit tickets via simple web interface
-  Web interface for end-users to have easily customizable forms to correctly route tickets
-  AD integration

-  Our existing helpdesk solution is HelpStar
-  We have about 1100 computers in hundreds of locations
-  We currently have a dozen support reps for various disciplines (application (5), desktop (3), network(1), other (3))

The Gartner recommendations are for large organizations deep into ITIL and Six-Sigma.  We aren't there yet.  Other expert-exchange solutions seem to be targeted at the small company.  We're somewhere in the middle and struggling to find an intuitive, easy to use, but robust solution.  I don't believe open-source or free solutions fit our business needs.

Recommendations?

linespliceAsked:
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mrtechsystemsCommented:

Might want to check out www.spiceworks.com out I am currently testing and its free

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Brian GeeCommented:
The Service-Now product is slowly taking over with such Help Desk processes in the mid-to-large level law firms I've seen over the past couple of years. Very robust product that does just about all you listed and more.

http://www.service-now.com/
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linespliceAuthor Commented:
Spiceworks has issues when working with around 1000 desktops.  We've tried it and the performance was too slow.
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derekrmooreCommented:
We use WebHelpDesk. http://webhelpdesk.com. Great for a ticketing solution, and can play nicely with other inventory/client management tools. AD integration is seamless.
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CianoxCommented:
I can suggest OTRS and Redmine
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shaffeiCommented:
We used to use Manage Engine before moving to HP Service Manager.

http://www.manageengine.com/

I think it's a good solution for mid-sized organizations.
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linespliceAuthor Commented:
Thanks for the suggestions.
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