I have a customer with a rather strange issue. He is the Manager of a local steam-cleaning company.
The third party program they use takes about twenty or thirty seconds to actually run after a period of inactivity. I removed the Sleep on LAN feature for each of the Network Cards and it didn't seem to make a difference... The other information I have is that this issue started about two months ago when the C drive on the Server (running Windows Server 2003) got close to being full. The third party company moved it to the D drive and then back to the C drive after they had a couple of issues with that.