Yesterday I used Malware Bytes to remove some fake AV malware, It was Antivirus 2011 or something like that, I don't remember exactly. Anyways, after rebooting from safe mode the malware was gone. However when the user launched Skype or GoToMeeting for example they would get an error saying "Application Not Found" I was able to launch it if I did run as and used the local administrator.
I ran a registry fix from the local admin but that did not resolve the problem.
Windows Registry Editor Version 5.00