Can't run exe from server Windows 2003 64bit Enterprise Edition sp2

lanman777 used Ask the Experts™
I am an administrator and can't run an exe from the local hard drive on my server?
What do I need to do? It says Windows cannot access the specified device, path or file
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Have you tried to unblock it?  Right click, properties, and then unblock?

Do you have the IE security installed under Windows components?
Is it a single EXE, or all?  Do you have any anti-virus software running?  Have you tried System Restore?

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