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This is a major security hole. I would not recommend it. You should consider somewhere else to store these settings, as giving write access to web.config opens up your whole server to a possible hack.<br />
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Changes to it will also cause restart of the app domain.<br />
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You need to edit the user under which IIS runs your app domain and give that user write privileges to that directory or file. I recommend you instead move these changeable settings to a different file, even if you must reference that file from web.config.<br />
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mrjlotcola - Can you please explain about security hole ? And what other option you recommend us to proceed ??
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VS 2008 / C#.Net<br />
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In run time, i need to edit or rewrite my config file. <br />
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We have a feature, for Admin can change folder, file settings on the .aspx page. These informations are stored on config file instead of database. Infact, i need to rewrite some of the database connection strings also.<br />
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How to write / rewrite (edit) a config file on runtime ??
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VS 2008 / C#.Net

In run time, i need to edit or rewrite my config file. 

We have a feature, for Admin can change folder, file settings on the .aspx page. These informations are stored on config file instead of database. Infact, i need to rewrite some of the database connection strings also.

How to write / rewrite (edit) a config file on runtime ??

Write on Web.Config file from C#

C# is an object-oriented programming language created in conjunction with Microsoft’s .NET framework. Compilation is usually done into the Microsoft Intermediate Language (MSIL), which is then JIT-compiled to native code (and cached) during execution in the Common Language Runtime (CLR).

The successor to Active Server Pages, ASP.NET websites utilize the .NET framework to produce dynamic, data and content-driven web applications and services. ASP.NET code can be written using any .NET supported language. As of 2009, ASP.NET can also apply the Model-View-Controller (MVC) pattern to web applications

ASP.NET

The .NET Framework is not specific to any one programming language; rather, it includes a library of functions that allows developers to rapidly build applications. Several supported languages include C#, VB.NET, C++ or ASP.NET.