Backup Exec 2010 R2 cannot use SAN Transport Mode to backup vCenter

IBM x3250M3 plugged a QLogic Dual-Port HBA Adapter
 - Backup Exec 2010 R2 , vCenter Server , NO VCB Installed as BE2010R2 claimed they don't need that anymore.

IBM x3650M3 plugged 2 x QLogic FC Adapter
 - VMware ESXi 4.1 ( Licensed vMotion , vStorage... etc )

IBM SAN Switch with 8 Port Enabled x 2
IBM DS3512 with dual controller ( currently I connect 2 pair from each controller to the SAN Switch A and B )

I assumed the FC connection is fine as usually I connect Port A to SAN Switch A and Port B to SAN switch B,
I can see the VMFS created from ESXi and successfully install guest OS without issue.

From the x3250M3 ( vCenter ) shows the LUN 29 ( same as it shows under ESXi ), the status is online and
heathly so I guess it fine too. However, I seems cannot backup anything by using SAN Transport Mode,
Backup Exec shows all vCenter and guest OS, I can tick them and everything sounds OK until I start the
backup job.

After the pre-processing of Backup Exec Job load, it returned Final error: 0xe0009585 - Unable to open a disk of the virtual machine.

I didn't set any special thing on the DS3512 and in fact I created a NTFS partition and I can have read / write access to it.

Can someone please give me a starting point where I can investigate it from ?

Thanks
William
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