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Exchange is the server side of a collaborative application product that is part of the Microsoft Server infrastructure. Exchange's major features include email, calendaring, contacts and tasks, support for mobile and web-based access to information, and support for data storage.
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Try safelist aggregation in Exchange 2010. Quoted from MS, "Safelist aggregation can help reduce the instances of false-positives in anti-spam filtering performed by the Edge Transport server. A false-positive is a positive test or filter result in a subject or body of data that doesn't possess the attribute for which the filter or test is being conducted. In the context of spam filtering, a false-positive occurs when a spam filter incorrectly identifies a message from a legitimate sender as spam."
link on how to do it : http://technet.microsoft.com/en-us/library/bb125168.aspx