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Win XP - Icons don't execute apps any more

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Last Modified: 2012-05-11
One of our Win XP boxs got hit with a virus or spyware. When we click an icon, it asks what application to run. I was able to send that email account an email with a link to Malwarebutes and Superantispyware.com which did find a few viruses but after the quarentine, removal and reboot, the same problem exists.

How do I resolve it?
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