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When you say not working ? What kind of error message are you getting ? 
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When you say not working ? What kind of error message are you getting ?

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Can you ping autodiscover.yourdomain?<br />
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Also see <a href="http://www.petenetlive.com/KB/Article/0000197.htm" rel="ugc">Your Out of Office Settings cannot be displayed, because the Server is currently unavailable. Try Again Later</a><br />
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There are quite a lot of causes for this and are you sure they are Outlook 2010? Outlook 2007 without SP3 also has a problem with this?
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Can you ping autodiscover.yourdomain?

Also see Your Out of Office Settings cannot be displayed, because the Server is currently unavailable. Try Again Later [http://www.petenetlive.com/KB/Article/0000197.htm]

There are quite a lot of causes for this and are you sure they are Outlook 2010? Outlook 2007 without SP3 also has a problem with this?

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 - and make sure your NOT going through a proxy server I've seen that cause this - as well as the user NOT being logged into the domain.
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- and make sure your NOT going through a proxy server I've seen that cause this - as well as the user NOT being logged into the domain.

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Can you please develop your own solution?
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Can you please develop your own solution?

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I have an issue where the Out of Office Assistant is not working in Outlook 2010. &nbsp;Not all users are effected just some. &nbsp;It is telling me the server is unavalible. &nbsp;I did some research and found little on this expect for the Autodicover which tested find. &nbsp;Any ideas?<br />
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They have Exchange 2007 and Outlook 2010
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I have an issue where the Out of Office Assistant is not working in Outlook 2010.  Not all users are effected just some.  It is telling me the server is unavalible.  I did some research and found little on this expect for the Autodicover which tested find.  Any ideas?

They have Exchange 2007 and Outlook 2010

Outlook 2010 Out of Office Assistant

Microsoft Outlook is a personal information manager from Microsoft, available as a part of the Microsoft Office suite. Although often used mainly as an email application, it also includes a calendar, task manager, contact manager, note-taker, journal, and web browser.

Outlook

Exchange is the server side of a collaborative application product that is part of the Microsoft Server infrastructure. Exchange's major features include email, calendaring, contacts and tasks, support for mobile and web-based access to information, and support for data storage.