i have an exchange 2010 server and outlook clients that are local can set their out of office.
i have just setup several rpc access clients an none are able to configure the OOF from outlook, only through OWA.
they all have the same error,
Your automatic reply settings cannot be displayed because the server is currently unavailable. Try again later.
All other features are working normally.
From what i understand, this is an issue with the autodiscover feature in exchange. there is a A record in place for autodiscover.domain.tld
The SSL cert is only for email.domain.tld