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Defraggler with exchange sever

Can I use Defraggler within a MS Exchange Server environment?
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tigermatt
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Yes, you can use defragging tools (taking into account the potential risks to your data, which, although small, there are still implications).

However, you should stop the Exchange Services, especially the Information Store service, to dismount the databases prior to commencing the operation. This ensures you won't floor the disks with I/O requests from both the defrag tool and Exchange. Those services - and therefore, your entire mail provision on that server - should be offline for the entire defrag operation.

-Matt
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Does he exchange server really need to be defragged? Or it's unecessary?
Defraggler  is used to defragment individual files and folders not for the exchange database. Please follow this below articles :-
http://www.windowsreference.com/free-utilities/defraggler-defragment-individual-files-and-folders/
If you want tol Defragment your Exchange Database, take a look at Lucid8 GoExchange

Accelerate Performance: Databases are re-indexed and defragmented to permanently remove white space and deleted items. The end result is increased performance and stability with a compact, efficient database     that's reduced in size by 30-55% and up to 90% or more when used in conjunction with an archiving solution.

Source
http://www.lucid8.com/product/preventative.asp

If you want to increase performance and prevent disks becoming fragmented take a look a trial Diskepper.

Diskeeper® data performance technology keeps systems free of fragmentation and delivers critical site-wide system efficiency automatically and cost effectively. Significantly increase the speed and reliability of even the busiest and most mission critical laptops, workstations, servers and enterprise servers – and make your budget go much further.
Source
http://www.diskeeper.com/products/business-windows/
My exchange server is a VM on hyper-v. Will compressing that VHD to get my free space back hurt the exchange server? I do it all the time on the file server with no problems. Want to see if this will also work with exchange server.
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Thanks guys Ill give that a shot.