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This is a fresh Backup Exec install, as we had the same problem with the previous version (12.5)
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This is a fresh Backup Exec install, as we had the same problem with the previous version (12.5)

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C:\Program Files\Symantec\Backup Exec\BkupLnch.exe<br />
<br />
This Application has failed to start because the applicayion configuration is incorrect. Reinstalling the application may fix this problem.<br />
<br />
Event Log<br />
SideBySide, ID32<br />
Dependant Assembly Microsoft.VC80.MFC could not be found and Last Error was The referenced assembly is not installed on your system<br />
<br />
SidebySide, ID 59<br />
Resolve a Partial Assembly failed for Microsoft.VC80.MFC. Reference error message: The referenced assembly is not installed on your system.<br />
<br />
SidebySide, ID 59<br />
Generate Activation Context failed for C:\Program Files\Symantec\Backup Exec\BkupLnch.exe Reference error message: The referenced assembly is not installed on your system.<br />
<br />
I have uninstalled and reinstalled C++ Redistributable 2005, 2008 and 2010 and rebooted. <br />
I have also reinstalled/repaired .Net Framework 2, 3, 3.5, and 4.<br />
<br />
Dont know what else to do!
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C:\Program Files\Symantec\Backup Exec\BkupLnch.exe

This Application has failed to start because the applicayion configuration is incorrect. Reinstalling the application may fix this problem.

Event Log
SideBySide, ID32
Dependant Assembly Microsoft.VC80.MFC could not be found and Last Error was The referenced assembly is not installed on your system

SidebySide, ID 59
Resolve a Partial Assembly failed for Microsoft.VC80.MFC. Reference error message: The referenced assembly is not installed on your system.

SidebySide, ID 59
Generate Activation Context failed for C:\Program Files\Symantec\Backup Exec\BkupLnch.exe Reference error message: The referenced assembly is not installed on your system.

I have uninstalled and reinstalled C++ Redistributable 2005, 2008 and 2010 and rebooted. 
I have also reinstalled/repaired .Net Framework 2, 3, 3.5, and 4.

Dont know what else to do!

Backup Exec 2010 will not start - C++ or .NET?

Windows Server 2003 was based on Windows XP and was released in four editions: Web, Standard, Enterprise and Datacenter. It also had derivative versions for clusters, storage and Microsoft’s Small Business Server. Important upgrades included integrating Internet Information Services (IIS), improvements to Active Directory (AD) and Group Policy (GP), and the migration to Automated System Recovery (ASR).

Windows Server 2003

The term "Backup" means the methods and processes involved to copy computer data (system data as well as application data) to media other than the ones where the data originally live (disk, tape, optical, cloud). "Restore" in turn means the methods and processes involved in data recovery, i. e., bringing back copied computer data to their original location. Backup/Restore primarily serves as a means of protection against data loss, be it due to disaster, corruption or sabotage. It can also be used for recovering data from an earlier point in time and even for cloning machines or applications. There is a wide variety of backup/restore software available, from expensive commercial products to free or open source tools.