troubleshooting Question

URGENT - SBS 2008 not sending and receiving email

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GerhardpetFlag for Canada asked on
ExchangeSBS
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I have a SBS 2008 with exchange 2007 not receiving and sending email

This the error I see in the queue
451 4.4.0 primary target ip address responded with 421 4.2.1 unable to connect

Everything was working fine until this morning when my customer called to let me know he was not receiving any emails. After I did a test I see that he is not receiving any emails either.
The email that the users are trying to send are all in the queue

Please help.
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