100ksearches.com virus

You need to scan your system for malware. When that is done, open your hosts file (c:\windows\system32\drivers\etc) and see if the redirect is in there. There should be no entries except comments. You need to be a member of administrators to do this. ... Thinkpads_User

Here's another problem, it won't allow me to run malwarebytes or any anti-virus software. And will not boot into safe mood.  

That is a much bigger issue than maybe we supposed at first. Given your last post, that machine is pretty much toast.

I would say try to restore to a prior period, but it is doubtful that would work.

You probably should back up the data and reinstall the operating system. In the state it is in (no A/V or Safe Mode), it could easily absorb more time in troubleshooting than in re-installing.

... Thinkpads_User

Can you try running Rkill:  Here is the download link

http://download.cnet.com/RKill/3000-8022_4-11464676.html

this is known to kill malware/virus processes and then try running other scanners

also you can try downloading on a usb stick from another computer and then run it on the infected pc

If I create a bootable CD with the latest security essentials virus definattion loaded. will that work?

And which security essentials would you recommend?

try Running Rkill to see if you can kill the virus process and run malwarebytes or combofix

if that doesnt work:

I would try a more in depth scanner than security essentials

Try making a cd ISO of kaspersky

Its a rescue disk and has worked wonders for me in the past with trojans/malware/viruses

download kaspersky rescue disk 10 here:

http://support.kaspersky.com/faq/?qid=208282173

Did you try running TDSSKiller? You have a TDSS rootkit and that is the appropriate tool. If TDSSKiller will not run, try running rkill as recommended above. Use the iExplore version of rkill.

Sorry for the ignorance, but, how do I run rkill?

just download rkill from the link above I posted earlier and click run, it takes care of the rest and runs through a command prompt

OK to run from CD?

Although not the same malware, this removal guide from Bleeping Computer has the instructions you need. Follow the removal instructions through step 17.
http://www.bleepingcomputer.com/virus-removal/remove-system-repair

Lastly run Malwarebytes, correct?

Yes.

Thank you. I'll update all tomorrow.

Well.... I ran Rkil then after-wards I was able to access msconfig and check the services  running at start up. I disable 2 fictitious malware, restarted and I was able to Google search  and access website.

Not sure if this fixed the problem, but I asked the end user to please monitor for any problem.

Through it all I was unable to run Malwarebytes.