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Backup to Disk - Best Practices

I'm now ready to back up to SAN and have everything ready to go and ran a few successful test runs. However, I don't know what the best practices are. I'm backing up Exchange DB, SQL BD and files. I read thereis a 2 TB limit on SAN Disks you can use to back up to? What are the best practices you are using? Do I create one folder for all backups or one for every job every day? Any info would be very helpful. I want to make sure to set this up correctly from the beginning. I'm using Backup Exec 2010.
Thanks.
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uescomp
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I do a daily backup of the servers and data, 1 weekly (internal and offsite), and 1 montly (internal and offsite).  I keep 10 backups of the dailies that de-dup to reduce taking up excessive space.  I hold on to 4 weekly backups and 3 montly backups.  Basically keep the backups from each quarter.

I plan to later have an offsite san for site replication (cross fingers for approval).  
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What about the file size liit of 2 TB?
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i manage it using acronis incremental backups
You can define the time and hours when and where u want to store it
I maintain a full backup and then the incremental backup files. It will save a lot of space and would not choke the network bandwidth.
Create separate folders and schedule the tasks in the respective folders to maintain the record