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asibiz

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Exchange server not sending or receiving messages

We have a 2003 exchange server that over the last month has had 3 strange events.  The server just stops receiving or sending messages.  There are no errors logged in the event viewer to indicate a problem with any of the exchange features or the server itself.  Twice the inetinfo.exe process had to be stopped and restarted for messages to sent or received.  Followed by the server having to be completely restarted.  The third time the information store had to be restarted for email flow to be restored.  I have never seen this before and need some advice.
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James H
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What is the size of the mailstore?
Any disk space issues?
Do you use any anti-spam / anti-virus software for exchange?
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asibiz

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The mailstore has is its own 1Tb drive.  Currently using Trend micro wfbs messaging security.  Checked for events relating to Trend and could not find any.  Checking through the console for the software for issues there but everything is functioning the way it is supposed to.
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Dug a little bit deeper into the exchsrvr folders.  Messages are still being received and stored in the queue folder but not being delivered to the users mailboxes.
SOLUTION
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Alan Hardisty
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(alanhardisty's suggestions are all good, but I would do what I suggested first as doing integrity checks on the database will mean a long period of downtime)
Would also temporarily switch off Trend and see if that has any effect
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I also had to go into the \vsi 1\queue folder and identify an old spam email that was not getting properly filtered into the quarantine.