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Running Windows Defrag on a Server Hosting Lotus Domino

I have a client with a Lotus Domino 8.x Server that is installed on a server running Windows Server 2003.  The hard drive on the server is in need of a defrag.  We are mostly an Exchange Server shop, so I'm not as familiar with the maintenance suggestions for a Domino server.

Do we need to take any precautions with the server before running a disk defrag? I plan to run a full backup prior to the defrag, and stop all Lotus Domino services/databases if necessary.  Any suggestions would be great.

1 Solution
I would suggest using Piriform's Defraggler.

It should not hurt anything.
Here's the official post from IBM:

Basically, it boils down to...
Administrators should check the hard disk regularly (at least once a month).
Run the Microsoft Disk Defragmenter tool on a regular basis:
There are several third-party tools available to defragment disks, even while the application is running:
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