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Hosting a critical application in MS Windows

What software should I be using if I am trying to make sure a MS SQL application has high availability.  Is ESXi a suitable candidate to do that?  Would you elaborate the process to provide high availability for hosting a critical application?
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Andrew Hancock (VMware vExpert PRO / EE Fellow/British Beekeeper)
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It is a CRM system that is strategic to the entire company operations. we would like to have it on 24 hours.  It can be down for 30 min to an hour max. Ideally no downtime.

Even when we expand our operations and need hardware upgrade, we like to be able switch over to new hardware without any downtime if possible.
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SQL Mirror on a seperate site with a witness server locally that can manage the quorum(sp?) and fail-over automatically.
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Thanks for all the help. Very informative.  I will post more specific questions for your further assistance. Thank.s