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Is it possible to create an Office 365 Word Document from a desktop application ?

Dear Expert:

I have developed a desktop application which generates a Word document using automation. I would like to know if it is possible to create a similar application for Office-365. So my question is: could a desktop application create and Access to a Word document on Orrice-365 by using automation ? For example, is it possible to use automation to Office-365 from Visual Basic 6 ?

Thank you.
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hellosan

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This helps me, but I would like to be sure.

Any other ideas ?
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