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Can't open various folders on various shares

I have a server that is having a very odd issue. It has a few mapped drives via logon script that point to a Windows 2008 R2 file server and a CIFS share on an EMC SAN. I can access the shares but some of the folders (20% of them) I can't access and when trying to do so it sits for about 1-2 minutes then say network resource not available. It is not a security issue as I can access all folders on any of 100's of other servers and workstations. I thought maybe a NIC issue so moved to a new nic, replaced the cable and new switch port. On top of that, it just happended on a hyper-v cluster shared volume (this is the 3rd node of a hyper-v cluster) which uses qlogic HBA's to an EMC VNX SAN.

I was thinking it's maybe a hardware issue with IO but it's always the same folders. I also tried a UNC connection \\server\share to a physical server and it happens there too. Not random folders but always the same.

The specs are:
Dell R710
98 Gig RAM
2 Intel 5520 Nahelam procs
Quad Broadcom 5309 NIC's onboard
2 QLogic QLE2460 HBA's
Windows Datacenter 2008 R2 SP1 with all updates
All firmware is up to date from SUU 6.5.1

Has anyone ever seen anything like this? I am working with Dell but in tier 1 support right now which usually takes hours of diagnostics to escalate so am hoping for a quicker resolution through you all.

Thanks for any ideas.
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1 Solution
Make sure you did not make a typo in the network config.
Subnet mask, gateway, dns, etc. I have seen systems work but be flakey when these are wrong.

Have you tried a XP client? Vista, Win 7, and 2008 use SMB 2.0 where XP uses SMB 1.0. This could help narrow the issue down to a SMB 2.0 issue.

Confirm drivers are up to date.

Is the server sluggish browsing folders using RDP or the console? If so, look at AV or SAN issues.

rparsons1000Author Commented:
Removed CPU & RAM that did not come with the server. Rebuilt from scratch and all seems good now. Slowly adding hardware back in.
rparsons1000Author Commented:
No viable solution
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