ESET NOD32 failed to protect us. Other options?

Windows XP:
One of our employees got infected by a virus. It hid his entire folder structure including all programs. He works remotly so he took it to a local computer repair shop. They said he was virused and it got through a fully updated ESET NOD32 and was somewhat stopped by Spybot.

The computer repair place was unable to tell me the name of the virus or where it came from.  I need to start looking into something more robust. This user uses our VPN and we cannot risk our severs being infected by one of our VPN users.

We have 6 servers (mix of W2K3 and W2K8) and 15 clients running NOD32 at the moment.

What are your suggestions?
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GWitekAsked:
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Rick HobbsConnect With a Mentor RETIREDCommented:
There is, unfortunately, no 100% solution.  I use a combination of trend an MalwareAntibytes,  But the only guarantee is a good backup. If possible, a real time backup.  If you have a good backup solution, even if not real time, the worst case is 1 day lost.  With the advent of multi Terrabyte USB drives, a fairly inexpensive, reliable backup solution is possible.  Even real time.  There are also multi TB network drive available.

Not knowing where your mail comes from, if you run an in-house mail solution, take a look at Barracuda for a reasonable Anti-SPAM, anti email virus solution.

But no one solution is 100% because the virus software company must respond to a new threat, and release a pattern file and you must implement the new pattern file before you are covered,  Another issue is user education.  If a user clicks on a file he thinks is from a friend that is actually spoofed, there is no defense AV solution or not.  Make regular images of your user's PCs to be able to re-image an infected PC rapidly.

And keep your fingers crossed - even Microsoft and the Federal government get hit occasionally.  
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