We are picking up intermittent problems with Outlook 2010 and 2007 disconnecting from Exchange server.
Most of the users that experience this problem is connecting via RPC over HTTP. Certificates installed OK, successfully connected and sent and received.
A contributing factor may be my LAN; different depts use different DG's (so bandwidth can be billed per dept). When working from pure internet connectivity, all seems OK, i.e. no disconnections, however when on the office LAN we pick up slow response and disconnections.