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Citrix is the synonym for the virtualization and application infrastructure systems developed by the company of the same name. Main areas are application virtualization, Software-As-A-Service (SaaS), cloud-computing and networking. The two most well-known are Citrix XenApp or Citrix CloudPlatform.
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Aything in the event logs?
It might be worthwhile monitoring with performance monitor to see if anything ramps up just prior to it happening.
It's been a long time since printer drivers were really able to cause this kind of behaviour, but it might be worth checking through which you have installed on the server and update them to the latest available.
Any AV software that might be causing problems?
How is the network in general when it happens?
The servers aren't virtual are they? I've seen this behaviour when storage connectivity is lost.