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Problem with DOCX Files

We are all on Microsoft Office 2007 as an upgrade or fresh install from Office 2003.  On some computers, if we receive an email with a DOCX, we need to save it to the desktop, remove the X and then it opens.  On yet others, this does not work, but if we save to desktop and File, Open, then it opens fine.  Any suggestions?
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etech0
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Can you save as docx?
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Once I can get it opened, I can file, save as DOCX, just like I can if I were able to open the file normally.
Office calls it Office 2007 format (DOCX), but since some users have this problem, we save as DOC sometimes (Office 2003 format).
what happens when you try to open docx? do you get an error?
also, if you create a docx, do you have trouble opening it?
When opening the DOCX file, Word opens, but just sits at a blank screen.  Self-created DOCX files work fine!
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Word opens though.  It just does not complete opening the file...
If you save it to the desktop and don't remove the x, do they open? If so, the problem may be with Outlook or whatever email program you use.
No, same problem.  I either need to remove the X, or open Word, then file, open the file with the X.  Very odd.
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In Word - Go to File, Options, Trust Centre, Trust Centre settings and check that the options are consistent across the copies that work and those that don't - especially make sure the message bar notifcations are turned on

The is a similar menu in Outlook but I don't have it here to see what's in it.

I am guessing that the file is being blocked from opening because its been flagged as from an unknown location
I will check that and get back to you.  Thanks!
Strange. Maybe someone else can help?...
Went through the settings, but the only thing I think might be blocking it is the “trusted locations” list.  Curiously, if I save the file and double click it from windows explorer I get the below message.

"There was a problem sending the command to the program."
Perhaps this link from above will help. Did you try it?
http://support.microsoft.com/default.aspx?scid=kb;en-us;307859&sd=tech
The setting was actually configured for Word Viewer!!!! Good thing I double checked!  Thank you for all your help!
I changed the file association to Word and all is well now.