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Access Denied to C Drive Windows 7

When I try and open any programs i am getting an access denied error.  If I try and go to computer and click on the C drive it won't let me view the content.

When i am in safe mode i can view all subfolders of the C drive except the actual root.

Any ideas?
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Yeah that was maybe going to be my next step.  Tried a system restore back to earlier this week but no luck.

Think combofix or malwarebytes are the best to run on it?
i know MalwareBytes has helped me in the past. I have not heard of combofix.

could also try AVG Free.. go with MalwareBytes first
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Run5k
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Won't even let me install anything bc it tries to write files to that drive.
If that's the case, it might be wise to start off by utilizing your pre-installed security/antivirus software and perform a full scan.
>>  Won't even let me install anything bc it tries to write files to that drive.   <<   connect the drive to another PC and scan it from there
if no pc available, use Kaspersky cd to scan it  http://support.kaspersky.com/viruses/rescuedisk
have you tried taking the ownership for C driver to administrator?
"When i am in safe mode i can view all subfolders of the C drive except the actual root."

Do you get the denial messages in Safe Mode as well?

Autoruns
http://live.sysinternals.com/autoruns.exe

I would be curious to see if you could produce an .arn file from this util.....

In the options above, please uncheck "Hide MS and Windows entries"..... Attach it here....
Hi Guys,
i was able to fix the problem by connecting the HD to another PC via a sata - usb cable and changed the permissions.

Thanks for the help
that is exactly what i posted -why no credit for me???