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Trouble opening files on desktop with RDS RemoteApps

Have an odd issue here.  We use Windows 2008 R2 RemoteApp and push the apps to PC's via MSI files and GPO.  Everything is working well, however, for one user, when they try to open any save Excel or Word files saved to their desktop, they get an error saying "The remote computer is not configured to open the type of data file that you are attempting to open".  This just started a few days ago.  I've checked everywhere on the server for file assosiations and it all looks good.  Any ideas?  Image attached.
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IT Manager
Did you try to delete the user profile so it creates a new one?


Thought about it, but posted here instead.  Just did and its fixed!  Curious what caused it...