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Post items to table from datagrid

I have a windows form with a datagridview.  the datagridview has 4 columns and is not bound to any dataset.  How can I take the values and post the 4 fields of data to a MS SQL db table with corresponding data/fields?
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Most Valuable Expert 2012
Top Expert 2014
Commented:
Use the dgv.Rows(index).Cells(index).value to retrieve the values.

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Commented:
Let me try