Exchange 2010 Delivery Failed

I am new to trouble shooting Exchange 2010 issues.  I am receiving reports of people getting delayed delivery messages and some delivery failed.  I am unsure of how to track down where the issue is and how to correct this, any help is greatly appreciated.

This is a 2008 R2 server.
Below is a message I received of a delivery failure.

Delivery has failed to these recipients or groups:

The server has tried to deliver this message, without success, and has stopped trying. Please try sending this message again. If the problem continues, contact your helpdesk.

Diagnostic information for administrators:

Generating server:

#550 4.4.7 QUEUE.Expired; message expired ##

Original message headers:

Received: from ([fe80::47:daa5:cdfb:c098]) by ([fe80::47:daa5:cdfb:c098%11]) with mapi; Thu, 15 Dec 2011
 16:51:11 -0600
From: Tom Anderson >
To: "Susan Walkup (
CC: Missy Johnson < 
Subject: West Liberty's Budget for MAG
Thread-Topic: West Liberty's Budget for MAG
Thread-Index: Acy7fAkxc5T7AHl4QXSx7yJzcXTPLA==
Date: Thu, 15 Dec 2011 22:51:09 +0000
Message-ID: <C07C67B24E2EBF41BD99968E89312D816300ED0B@ >
Accept-Language: en-US
Content-Language: en-US
X-MS-Has-Attach: yes
Content-Type: multipart/related;
      boundary="_004_C07C67B24E2EBF41BD99968E89312D816300ED0B _";
MIME-Version: 1.0
Who is Participating?
Shivkumar SharmaOperations Delivery ManagerCommented:
Refer -

Numeric Code: 4.4.7

Possible Cause: The message in the queue has expired. The sending server tried to relay or deliver the message, but the action was not completed before the message expiration time occurred. This NDR may also indicate that a message header limit has been reached on a remote server or that some other protocol timeout occurred during communication with the remote server.
Troubleshooting: This code typically indicates an issue on the receiving server. Verify the validity of the recipient address, and verify that the receiving server is configured to receive messages correctly. You may have to reduce the number of recipients in the header of the message for the host that you are receiving this NDR from. If you resend the message, it is placed in the queue again. If the receiving server is on line, the message is delivered.
brranceAuthor Commented:
Thanks for the reply.

I just ran the Troubleshooting Assistant and got and an error message of "Error accessing performance counter data on server {server name}. Unknown error (0xc0000bb8)
brranceAuthor Commented:
This issue has been resolved.  There was an issue with the config between our email server and Postini.  Please award Shivkumar the points, as his post pointed me in the right direction to uncover where the issue was.

Thanks for all your help.
Shivkumar SharmaOperations Delivery ManagerCommented:
Thank you, You may accept my solution to award me points if you wish to do so
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