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If you open up Exchange Management Console, then navigate to Org Config&gt; Hub Transport&gt; Remote Domains Tab&gt; Default&gt; Properties of Default&gt; General Tab.<br />
<br />
Make sure you have the Allow External out-of-office messages and legacy out-of-office messages enabled.
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If you open up Exchange Management Console, then navigate to Org Config> Hub Transport> Remote Domains Tab> Default> Properties of Default> General Tab.

Make sure you have the Allow External out-of-office messages and legacy out-of-office messages enabled.

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Out of Office will enable in Outlook but will not send any reply messages to external email addresses. <br />
I am using a workstation using office 2010.<br />
I ran a test connectivity and noticed the OOF url is not accessible from the outside.<br />
<br />
Does the OOF Url need to accessible from the outside in order for it so send outbound reply messages?<br />
<br />
Thank You.
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Out of Office will enable in Outlook but will not send any reply messages to external email addresses. 
I am using a workstation using office 2010.
I ran a test connectivity and noticed the OOF url is not accessible from the outside.

Does the OOF Url need to accessible from the outside in order for it so send outbound reply messages?

Thank You.

Out of office does sent reply Exchange 2010 and Outlook 2010

The Microsoft Server topic includes all of the legacy versions of the operating system, including the Windows NT 3.1, NT 3.5, NT 4.0 and Windows 2000 and Windows Home Server versions.

Microsoft Server OS

Microsoft Outlook is a personal information manager from Microsoft, available as a part of the Microsoft Office suite. Although often used mainly as an email application, it also includes a calendar, task manager, contact manager, note-taker, journal, and web browser.

Outlook

Exchange is the server side of a collaborative application product that is part of the Microsoft Server infrastructure. Exchange's major features include email, calendaring, contacts and tasks, support for mobile and web-based access to information, and support for data storage.