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Exchange Server 2010 452 4.3.1 Insufficient system resources

All of our incoming email is delivered to a spamfilter appliance and then to our Exchange 2010 server.  Email is being received by the spamfilter but when the spamfilter tries to send it to the Exchange server I am getting a 452 4.3.1 Insufficient system resources error.  I have 1.2TB of free space on the database volume and 80GB of free space on the log volume so it's not a space issue.  I think I have disable the Back Pressure Feature but not sure how to tell.  I edited the C:\Program Files\Microsoft\ExchangeServer\V14\Bin\EdgeTransport.exe.config file on the line gcserver enabled=”Yes” /> I changed it the “Yes” to “False” and restarted the Microsoft Exchange Transport service.  
Our company email which goes thru the Exchange Server is working and we can send email out but I can’t get the incoming email to the Exchange Server.
Any Help would be greatly appreciated.
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Alan Hardisty
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You are suffering from Backpressure!  Low resources on your Exchange server - usually a lack of disk space.

Please have a read of my article for a quick fix, then implement a longer fix by seeing why your disk space is being eaten up or if your memory is being chewed up by a process:

https://www.experts-exchange.com/Software/Server_Software/Email_Servers/Exchange/A_4259-Exchange-2007-2010-Backpressure-Quick-Fix.html

Are you running an 'Exchange Aware' backup and thus your Exchange logs are being purged, or are your logs eating up the disk space?
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scoombs1

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I have 1.2TB of free space on the Database volume and 80GB of free space on the Log volume.  I think I have disabled Backpressure.  How can I verify that its disabled?  CPU is at 40% and Memory is at 55%.
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Alan Hardisty
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Bear in mind that once you disable backpressure, you have to restart the Transport Service, so the memory in use after you restart the service will be lower than before you restart it, so prior to starting it could be eating up your resources, but afterwards, for a while, it should be much lower.
scoombs1

Try bypassing the spam filter and see if this still causes the issue. You could always setup a spam filter of your own in 2010 which looks at spam sites to do the filtering as well.  

But I have to agree with alanhardisty it could be the memory of the server. 2010 does require larger amounts of RAM to run efficiently.
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