Programs time out trying to open- Server Slow- Logon Slow

I am out of ideas on what is going on---

Servers-- 2 Dell R710 one has 96 GB ram the other 128, ESXI 4.2, 3 data stores each 2 SSD & 1 SATA, 4 NIC cards, 16 logical proc.

Box 1 has - 10 virts 2 of them TS - server 03
Box 2 has - 7 virts 4 of them TS 3 server o3 & 1 server 08
each TS has 8 gb memory allocated to it and 4 cpu
split network across the NIC's so no more than 2 TS to 1 NIC  all connected to GB ports

here is the issue-
about a week ago i started having really crappy performance, some applications werent opening, other timed out. To logon took over 5 minutes. I have looked at everything i can think of-
1. ran dns diag on DC-- ok
2. cleared dns and temp on TS
3. watched memory, cpu, and disk on TS-- normal
4. watched network traffic on switch-- ok
5. process explorer -- nothing abnormal
6. 100 other things.

the one program is a custom VB program that connects to our erp database.
another is a maintenacne program that connects to sql -- Different servers
but all in all it is just running so slow. i thought maybe my hard drives were going bad but different hosts and different data stores.
The problem does not seem to be consistant either. one minute the programs work ok on one server then they start crapping out, same with the others.
I have checked the event logs -- have some errors about gp and start menu but that is about it.
The VB application is installed local on TS - have a logon script that puts and icon on the desktop that points to shared folder on file server- its a click once app.
i have done all the usual --reboots, reg scans, clearing temp files, etc.
There is not av on the TS

Any thoughts on where to go next??
optikconnexAsked:
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Stephen McTigueAssistant Director of Information TechnologyCommented:
It sounds like a potential issue with your domain controller, especially since it's taking so long to log on. Also check in vSphere and verify that the hosts are using the NTP time server on the network. If the hosts time becomes too far off from the time server, I've seen weird things occur with the virtual servers.

Regards...
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optikconnexAuthor Commented:
We have 2 DC running and i have run dcdiag on both, results on both were passed.
I checked the time settings on the hosts one was off about 6 minutes the other was good.
I updated the one that was not correct.
so far today it looks like 3 of the 5 TS are doing ok. The 2 that arent playing nice are on different hosts.
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optikconnexAuthor Commented:
Ok so I think i have it tracked down to DNS.
ping the dns server by name -- fine.
tracert to dns server by name-- fine.
but
nslookup to dns server by ip or name  -- slow, very slow.
it appears to be worse after the server has been running for a while. right after a reboot it is much quicker.
the rest of the machines on the netowrk appear fine.
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optikconnexAuthor Commented:
played with DNS until it worked again.
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Windows Server 2003

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