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New Exchange setup with 450 mailboxes - recommend solution

I have a customer that's moving from Google Apps to their own Exchange system with 450 mailboxes. I've setup and configured a large number of Exchange servers but never one that is going to host this many mailboxes. (We are going to use Dell servers)

Can/should this be done on a single server?
Virtual or non-virtual?
Enterprise Exchange or Standard Exchange?
15K RPM drives?

Any help is appreciated.
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Grimmway

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Great...thanks.