I have a newly set up Windows 2008 R2 Standard Remote desktop services server which (for just one user) I can't open Outlook 2003. It says "Unable to open your default folders. The information store could not be opened". All other users connect to Exchange 2007 fine. I have reinstalled Outlook, recreated two diffrent profiles, installed Office 2003 SP3, excluded Outlook and Word from DEP on the server, ensured that the user is a local admin, and tried starting Outlook in Safe-mode. Driving me crazy tonight. Please help. i noticed that there was another question posted with the exact problem, but it didn't have an answer. Any help you could provide would be greatly appreciated.