exchange 2003 mailbox maintenance never ran should I run

I have an exchange 2003 mailbox store.  On the limits tab of the store properties the box for "do not permanently delete mailboxes or item until the store has been backed up" is checked.  My store is approximately 125 GB.  

If I uncheck this box do you think it will cause any issues with the store running ok?  It has not been unchecked in five years.  I don't want to take off line if I don't have to.  I backup the database with symantec backup exec and I am getting errors.  I figured this would reduce my mailbox store size and help on backups.  I don't want the maintenance process to cause any problems due to the fact that it probably has so much to do.  I hate for my mail store to quit in the middle of the day.  Thank you for any help you might give.
MHMCadminAsked:
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Elmar KoschkaSenior System EngineerCommented:
you loose the files they are deleted and not backuped. but nothing else.
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PradeepCommented:
If you check this option the mailboxes or items will not be deleted until the store is backed up.
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MHMCadminAuthor Commented:
Thank you very much.  I am looking more for a recommendation of the maintenance running after "not" running after five years and possibly freezing up the mailbox store.  Has anyone ever unchecked this box and five years works of files and mailboxes been deleted during the maintenance process and had any trouble with the mailbox store freezing up.  Thank you !!
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Elmar KoschkaSenior System EngineerCommented:
3 years ago i had the same proplem with a exchange server from customer. but only for 4 years. they problems a solved since i unchecked this option.
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MHMCadminAuthor Commented:
Great.  During the process did it cause any issues with mail flow or the store?  This is my biggest concern.  Glad to hear it fixed issues.
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Elmar KoschkaSenior System EngineerCommented:
for the future you can create a second mailbox store and move some mailboxes to the other store.
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Elmar KoschkaSenior System EngineerCommented:
you should do this at night. depends of your hardware, i dont think there are problems for mail flow or any other.
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