Constant Requests for Credentials when accessing documents

We have a Sharepoint 3.0 Install running on Server 2008R2, and users are suddenly getting requests for credentials every-time they try and access documents. The prompt bounces back as though the credentials are invalid even though they are not. It will even lock the user's account out. Odd thing is they can cancel out of the prompt and still access the file. Where would I start to troubleshoot this?
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colly92002Connect With a Mentor Commented:
I don't know the answer to this, however it can't hurt to make sure you user profiles are sync-ed to AD properly.

To do this, follow the instructions here:
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